Polypeptide Oxytocin for Hasten Parturition

Name Oxytocin Acetate
Other name Atonin,Endopituirina,Orasthin,Oxytocinum
CAS No 50-56-6
EINECS 200-048-4
Molecular formula C43H66N12O12S2
Single Impurity(HPLC): 1.0%max
Amino Acid Composition: 10% of theoretical
Mass Balance: 95.0~105.0%
Water Content(Karl Fischer): 6.0%
Assay 98%
Appearance: White powder

 

Oxytocin Application:

 Oxytocin is a hormone that is made in the brain, in the hypothalamus, and it is transported to, and secreted by, the pituitary gland, which is located at the base of the brain.

Chemically it is known as a nonapeptide (a peptide containing nine amino acids), and biologically, as a neuropeptide. It acts both as a hormone and as a brain neurotransmitter. In both men and women, sexual intercourse stimulates the release of oxytocin, which has a role in erection and orgasm. The reason for this is not fully understood, although in women, it has been proposed that the increased uterine motility may help sperm to reach their destination.

The research to uncover oxytocin’s “anxiolytic and pro-social influences, beneficial to relief, reproduction, and love” is what has led scientists to describe it as a one of the “most promising neuromodulator/neurotransmitter systems of the brain for psychotherapeutic intervention and treatment of numerous psychiatric illnesses, for example social phobia, autism, and postpartum depression.

 

Usage and Dosage:

Odinopoeia or oxytocin intravenous drip, once the 2.5 – 5 units, with Sodium Chloride Injection diluted to each 1ml contains 0.01 units. Intravenous drip of the beginning of every minute of not more than 0.001 to 0.002 units, each 15 – 30 minutes increased 0.001 to 0.002 units, to achieve the contractions and normal childbirth is similar, the fastest per minute of not more than 0.02 units, usually 0.002 to 0.005 units per minute.
Control postpartum hemorrhage per minute intravenous drip of 0.02 – 0.04 units, expulsion of the placenta after intramuscular injection of 5 to 10 units.
Lactogenic just before a 2 – 3 minutes, with nasal drops a 3 drop, drop into one side or both sides of the nostril.

Preparation and specification : oxytocin injection (1) 0.5ml:2.5 units (2) 1ml:5 (3) 1ml units 10 units;
Oxytocin nasal drops 1ml:40 units. The induction of labor or prenatal uterine atony: in 2.5-5 units in 500ml 5% glucose for intravenous drip slowly (10-30 drops / minute), maximum time 20 units. (2). Prevention of postpartum hemorrhage: intramuscular injection of 5-10 on each unit, or 5% glucose solution for intravenous drip.
The main contraindication, heart disease, a caesarean history and more than three fetal maternal disable.

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