Bp: 868.9 °C at 760 mmHg
Fp: 479.3 °C
Specific optical rotation: +79.3°
Loss on drying: 0.15%
Free heptanoic acid: 0.10%
Related substances: ≤2%
Appearance: white powder
Package: 1g; 10g; 100g; 500g; 1kg
Storage: At room temperature
Ibutamoren (MK-677) Description:
MK-677, acts as a potent, orally active growth hormonesecretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including growth hormone and IGF-1, but without affecting cortisol levels. It is currently under development as a potential treatment for reduced levels of these hormones, such as in growth hormone deficient children or elderly adults, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly. It also alters metabolism of body fat and so may have application in the treatment of obesity.
Ibutamoren (MK-677) benefits:
In a study on it’s effects on catabolic states, a once daily oral dose of 25mgs was given to healthy young men subjected to short-term diet-induced nitrogen wasting. After 7 days of this dose, the subjects showed a sustained increase in serum concentration of IGF-1 and Growth Hormone; in addition, the nitrogen wasting was reversed, showing great potential for treatment of conditions involving muscle wasting.
A study done for the treatment of osteoporosis and bone mineral density showed some increase in bone density, so there is a true impact on bone mineral density. This can help with injury recovery during your cycle.
Ibutamoren (MK-677) Applicaition:
MK-677 is an orally administrated growth / hormone secretagogue originally developed by Reverse Pharmacology. A secretagogue is the term for a substance that chemically signals for the pituitary gland to secrete . In other words, MK-677 could be compared to peptides like GHRP-6 or Ipamorelin, only it doesn’t require any injections nor does it have any side effects like GHRP-6. This GHS (Growth / Hormone Secretagogue) was developed in an aim to combat such conditions as muscle wasting, obesity and osteoporosis. It was also targeted towards treatment of elderly hip fracture patients, so there are a myriad of studies done on safety.
How Ibutamoren (MK-677) WORKS?
Growth hormone pulse intensity can be increased through 4 possible mechanisms:
Increasing GHRH (growth hormone releasing hormone) release.
Amplifying GHRH signaling in somatotrophs of the anterior pituitary gland.
Reducing somatostatin release (somatostatin turns off GH release).
Inhibiting of somatostatin receptor signaling.
Ibutamoren (MK-677) was found to work through all four of these mechanisms. After ingestion, Growth Hormone (GH) was shown to increase dose dependently, at doses starting at 5 milligrams (mgs) a day.
The effect of MK-677 :
1. Fat loss
2. Lean muscles
3. Tightening up loose skin.
4. Healing old injuries.
5. Healing Bones, Tendons and Ligaments.
6. In fact, many users report growing up to 6 lbs of lean muscle mass in 8 weeks of IGF-1 only cycles.
Growth hormone pulse intensity can be increased through 4 possible mechanisms
1. Increasing GHRH (growth hormone releasing hormone) release.
2. Amplifying GHRH signaling in somatotrophs of the anterior pituitary gland.
3. Reducing somatostatin release (somatostatin turns off GH release).
4. Inhibiting of somatostatin receptor signaling.
Nutrobal (Mk-677) was found to work through all four of these mechanisms. After ingestion, Growth Hormone (GH) was shown to increase dose dependently, at doses starting at 5 milligrams (mgs) a day.