Donepezil is a centrally acting reversible acetylcholinesterase inhibitor. Its main therapeutic use is in the palliative treatment of Alzheimer’s disease. Common side effects include gastrointestinal upset. It has an oral bioavailability of 100% and easily crosses the blood-brain barrier. Because it has a biological half-life of about 70 hours, it can be taken once a day.
Donepezil has been tested in other cognitive disorders (and is sometimes used off label) including Lewy body dementia and vascular dementia, but it is not currently approved for these indications. Donepezil has been found to improve sleep apnea in Alzheimer’s patients. Donepezil has also been studied in patients with Mild Cognitive Impairment, schizophrenia, attention deficit disorder, post-coronary bypass cognitive impairment, cognitive impairment associated with multiple sclerosis, CADASIL, and Down syndrome.
A 3 year NIH trial in patients with mild cognitive impairment reported that donepezil was superior to placebo in delaying rate of progression to dementia during the initial 18 months of the study but this was not sustained at 36 months. In a secondary analysis, a subgroup of individuals with the Apolipoprotein E4 genotype showed sustained benefits with donepezil throughout the study. However at this time donepezil is not indicated for prevention of dementia. Recent studies suggest that Donepezil can improve speech in children with autism. The studies found that speech of autistic children who were mild to moderately affected appeared to improve from the use of Donepezil.
|Appearance||Off white to white crystalline powder||Complies|
|Solubility||freely Freely soluble in chloroform, soluble
in water and Acetic acid, slightly soluble in
Acetonitrile and ethanol, insoluble in
Ethylacetoacetate and n-hexane
|Identification||(1)By IR absorption ,To match with working
|(2) The retention time of the major peak of
the sample should accord with that of the
|(3) Test for chlorides. Reponds to the test
|Residue on ignition||≤0.1%||0.03%|
|Related substance||Any Unkonwn single impurity≤0.3%
|Loss on drying||≤0.5%||0.20%|
|Assay||On dried base, C24H29NO3·HCl
should be 98.0% to 102.0%
|Conclusion: The product complies to Enterprise standard|