Digestive system agents Omeprazole for Treatment Peptic Ulcer

Quich Details:

Name: Omeprazole
CAS No.: 73590-58-6
MF: C17H19N3O3S
MW: 345.42
EINECS: 201-212-8
Melting point: 156°C
storage temp.: 2-8°C
solubility: H2O: 0.5 mg/mL
Chemical Properties: White Crystalline Solid
Usage: Binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative

 

Omeprazole Specification

ITEMS STANDARD RESULTS
Identification A: By TLC positive
B: IR Conforms to standard positive
Completeness of solution Conforms to standard positive
Color of solution The absorbance is not greater than 0.1 at 440nm 0.04
Loss on drying ≤0.5% 0.2%
Residue on ignition ≤0.1% 0.04%
Heavy metals ≤0.002% <0.002%
Chromatographic purity(HPLC) Single impurity ≤0.3% 0.12%
Total impurity ≤1.0% 0.28%
Residual solvent a)Acetone ≤ 5000ppm 554ppm
b)Methylene ≤600ppm 12ppm
c)Methanol ≤ 3000ppm 50ppm
  ≤ 890ppm 28ppm
Assay(HPLC) 98.0%-102.0% 99.9%

Description

Omeprazole, sold under the brand names Prilosec and Losec among others, is a medication used in the treatment of gastroesophageal reflux disease,peptic ulcer disease, and Zollinger-Ellison syndrome. It is also used to prevent upper gastrointestinal bleeding in people who are at high risk. It can be taken by mouth or injected into a vein.

Omeprazole was discovered in 1979.It is on the World Health Organization’s List of Essential Medicines, the most important medications needed in a basic health system.It is available as a generic medication. The wholesale cost in the developing world as of 2014 is 0.01 to 0.07 USD per dose. In the United States it costs about 1.00 USD per pill.
 
Common side effects include nausea, vomiting, headaches, and increased intestinal gas. Serious side effects may include Clostridium difficilecolitis, an increased risk of pneumonia, an increased risk of bone fractures, and the potential of masking stomach cancer. It is unclear if it is safe for use in pregnancy. Omeprazole is a proton pump inhibitor and as such blocks the release of stomach acid.

 

Omeprazole Applications

Omeprazole can be used in the treatment of gastroesophageal reflux disease, peptic ulcers, erosive esophagitis, and Zollinger-Ellison syndrome. 

Gastroesophageal reflux disease: Gastroesophageal reflux disease (GERD) is a chronic condition in which acidic stomach content leaks back into the esophagus and irritates it. It may cause heartburn, which is a painful burning feeling in the chest or throat. 

Peptic ulcers: Peptic ulcers are sores that develop in the lining of either the stomach or the duodenum due to damage from stomach acid. The most common cause of a peptic ulcer is infection by Helicobacter pylori. Another major cause of a peptic ulcer is long term usage of non-steroidal anti-inflammatory drug(NSAIDs), such as aspirin or ibuprofen. Treatment of Helicobacter pylori infection can be completed by taking a triple therapy combination of omeprazole, amoxicillin, and clarithromycin for 7-14 days. 

Erosive esophagitis: Erosive esophagitis is due to tissue damage to the lining of the esophagus, because of inflammation or irritation over time. It may be caused by acid reflux from GERD, infection by a virus or fungus, an autoimmune disorder, certain medications, or alcohol abuse. 

Zollinger Ellison syndrome: Zollinger Ellison syndrome is a rare disorder that occurs when a tumor of the pancreas or duodenum releases a hormone that stimulates overproduction of stomach acid. This condition may form multiple peptic ulcers. 

 

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