Alias: 4-androstene-3,6,17-trione; Androst-4-ene-3,6,17-trione
Application: The 3,6,17-androstenetrione is commonly used in testosteron builders and estrogen blockers. Typically marked too the bodybuilding community, this ingredient has no weight loss or fat burning effects. In addition to the sheer lack of benefit for dieters trying to loss weight, none of the claims are proven though clinical studies are cited as being available.
4-Androstene-3,6,17-trione (4-AT; also marketed as 6-OXO or 4-etioallocholen-3,6,17-trione) is a drug or nutritional supplement that may increase the testosterone-estrogen ratio, but has no proven effect on body composition. Its use can be detected in urine.
4-Androstenetrione is a potent irreversible aromatase inhibitor that inhibits estrogen biosynthesis by permanently binding and inactivating aromatase in adipose and peripheral tissue.Aromatase is responsible for the conversion of testosterone to estradiol. Blocking aromatase causes the body to decrease in levels of estradiol, which then results in increase of LH and consequently, testosterone. Since testosterone has myotropic activity and estradiol does not, elevated testosterone levels increase muscle mass. However, there appear to be no human or animal studies testing the hypothesis that 4-AT will produce an anabolic effect.