Dyclonine HCI

Dyclonine HCI

Name Dyclonine hydrochloride
Other name Dyclonine HCI
CAS No. 536-43-6
Molecular formula C18H28ClNO2
Molecular weight 325.87
EINECS 208-633-6
Appearance White or off white crystalline powder
Standard adopted USP 28
Melting Pcint 174.5-176.5ºC
Acidity 5.6
Loss on drying 0.42%
Resdue on ignition 0.06%
Assay 99.8%



Dyclonine is an oral anaesthetic that is the active ingredient of Sucrets,an over the counter throat lozenge.It is also found in some varieties of the Cepacol sore throat spray.It is a local anesthetic,used topically as the hydrochloride salt.

Dyclonine hydrochloride has been found to possess,in addition to its topical anesthetic properties,significant bactericidal and fungicidal activity.Self-sterilizing action manifested by preparations containing the drug was considerably enhanced upon the addition of chlorobutanol.

Results of in vitro tests employing microorganisms commonly involved in local infections indicated that the two agents in combination act synergistically.



This product should be formulated as a 1% cream, ointment or 0.5 to 1% of the agent, trauma, insect bites hurt a few kinds of skin itching symptoms of pain that is excellent itching, bactericidal anti-inflammatory effect. It can also be used to control a variety of allergy symptoms.


Usage and Dosage:

1.Local external use: apply adequate amount to the affected area and its surrounding, 1-2 times a day. Ringworm of the body, 2-4 weeks, tinea of feet and hands, tinea versicolor, 4 to 6 weeks.

2.Oral: 0.25 grams each time for adult, once per day, period of treatment is as follows:
Skin infection treatment: tinea of feet and hands [toe (means) and plantar]: 2 ~ 6 weeks; Ringworm of the body, tinea, 2 ~ 4 weeks.

3.Skin candidiasis: 2 ~ 4 weeks. normal skin appearance and loss of infection can only be visible in a few weeks for curing.

4.Hair and scalp infection treatment: tinea capitis: 4 weeks, tinea capitis most happen in children.
Onychomycosis: The most treatment course of patients is 6 weeks to three months. Young patients with normal growth can shorten the treatment course, and less than 3 months of treatment may be enough in addition to the thumb (foot) armour.

5.In other cases, the treatment is usually 3 months. Some patients, especially whose thumb (toe) infected, may take 6 months or longer. The treatment may take more than 3 months if the nail grew slowly in the first week. In healing of mycology and stopping for a few months after treatment, the continuous improvement of nail appearance then completely normal can be seen, this is because that the healthy tissue growth needs time.