Toremifene Citrate

Toremifene Citrate

Name:Toremifene Citrate
Synonyms:fareston;(z)-4-chloro-1,2-diphenyl-1-(4-(2-(n,n-dimethylamino)ethoxy)phenyl)-1-butene;(z)-2-[4-(4-chloro-1,2-diphenyl-1-butenyl)phenoxy]-n,n-dimethyl-ethanamine 2-hydroxy-1,2,3-propanetricarboxylate
CAS:89778-27-8
MF: C32H36ClNO8
MW:598.08
MP:160-162°C
BP:146-148C
Density:1,045g/cm
Refractive Index:1,416-1,418
Chemical Properties:White to off-white solid
Usage:An antiestrogen and antineoplastic. Nonsteroidal antiestrogen structurally similar to Tamoxifen.
Packing:Foil bag

 

Toremifene citrate  Application:

Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body. Licensed in the United States under the brand name Fareston, toremifene citrate is FDA-approved for use in advanced (metastatic) breast cancer. It is also being evaluated for prevention of prostate cancer under the brand name Acapodene.

It has already been covered that Toremifene is a SERM, and serves to block Estrogen at various receptor sites in certain tissues within the body (breast tissue in particular). As a layman explanation, Toremifene pretends to be a ‘fake’ Estrogen that occupies Estrogen receptors within breast tissue. With these receptors occupied by Toremifene, real Estrogen cannot perform their jobs there. Toremifene does not reduce total blood plasma levels of Estrogen. In addition to being antagonistic to Estrogen receptors in breast tissue, it is also antagonistic to Estrogen at the hypothalamus gland (this essentially ‘tricks’ the hypothalamus into thinking there is little or no circulating Estrogen levels in the body, causing it to increase its manufacture of Testosterone so that it can utilize aromatization to restore these levels

 

Toremifene citrate  COA:
 

TEST ITEMS SPECIFICATION RESULTS
 Description White or Almost White Crystalline Powder White  Powder
 Identification Positive Positive
 Assay 97.00~103.00% 99.38%
 Loss On Drying 0.5%max 0.25%
 Melting Point 95~99¡ãC 96.0~98.0¡ãC
 Specific Rotation +48¡ã~+51¡ã +49.0¡ã
 Organic Volatile Impurities meets the requirments. Conforms
 Residual Solvents meets the requirments. Conforms
 Conclusion The specification conform with USP32 standard